Drugs & Vitamins

PACIS Active Ingredients: Bacillus Calmette-Guerin Vaccine Intravesical Solution Representative Names: PACIS, TICE, TheraCys What is BCG Live intravesical solution? What should I tell my health care provider before I take this medicine? How should I use this medicine? What if I miss a dose? What drug(s) may interact with BCG Live intravesical solution? What side effects may I notice from receiving BCG Live intravesical solution? What should I watch for while taking BCG Live intravesical solution? Where can I keep my medicine? What is BCG Live intravesical solution? (Back to top) BCG Live Intravesical solution (PACIS®, TICE® BCG, TheraCys®) is a bacteria that is used to stimulate your body's immune system against certain types of superficial cancers, especially bladder cancer. Generic BCG Live intravesical solutions are not available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •fever or infection •active tuberculosis or a positive skin test for tuberculosis •blood in the urine •bladder biopsy within 2 weeks •an immune deficiency (natural or due to cancer chemotherapy, radiation, or steroid therapy) •an unusual or allergic reaction to vaccines, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I use this medicine? (Back to top) BCG intravesical solution is placed within the bladder through a catheter. It is usually given by a trained health care professional in a hospital, clinic or prescriber's office. Do not drink any liquids 4 hours before you receive BCG intravesical solution. Empty your bladder just before the treatment is given. You will need to hold this solution in your bladder for at least 2 hours. Treatments are usually given weekly for 6 weeks. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) It is important not to miss a dose. Let your prescriber or health care professional know if you are unable to keep an appointment. What drug(s) may interact with BCG Live intravesical solution? (Back to top) •medicines that suppress your immune system such as chemotherapy agents or corticosteroids •medicine to treat tuberculosis Because BCG intravesical solution is given into your bladder, there is very little absorption into the rest of your body. Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from receiving BCG Live intravesical solution? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •blood in urine •fever, chills, or other signs of infection •increased or new cough •nausea or vomiting •skin rash Side effects that usually do not require immediate medical attention (report these side effects to your prescriber or health care professional if they continue or are bothersome): •bladder spasm •bladder pain •burning when urinating •difficulty urinating •flu-like symptoms •having to urinate often •unable to control urination •waking up at night to urinate Most side effects occur after placing BCG intravesical solution in your bladder and may last up to 7 days. What should I watch for while taking BCG Live intravesical solution? (Back to top) Visit your prescriber or health care professional for regular checks on your progress. BCG Live intravesical solution contains live bacteria. If you have an immune deficiency or have lesions in your bladder that have not healed, you may be at increased risk to get an infection due to this bacteria. If you develop a cough, have a fever more than 103 degrees F or a fever that lasts longer than 3 days, or bladder symptoms that do not go away, call your presciber or health care professional. You may have developed an infection that needs treatment with certain antibiotics. For 24 hours after receiving BCG Live intravesical solution, urinate by sitting down on the toilet. After you urinate, add 2 cups of chlorine bleach to the toilet bowl. Let stand for at least 15 minutes before flushing. Repeat this process each time you urinate for 6 hours after each treatment. Make sure to wash your hands and genital area thoroughly after you urinate. Drink several glasses of water a day after taking BCG intravesical solution to wash out your bladder. Side effects after BCG intravesical may not be bothersome until after the third treatment. Side effects may gradually get worse after each administration. Men and women of childbearing age should use effective birth control methods during BCG intravesical treatment. Women should not become pregnant while being treated with BCG intravesical solution. Where can I keep my medicine? (Back to top) This medicine is given into your bladder at a clinic or hospital. You will not be given doses to store at home. Last Updated:03/24/2000 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.